User:Doc James/CTX2
Serum sickness is a type of allergic reaction to non-human proteins.[1] Symptoms commonly include fever, rash, and joint pain.[2] It generally occurs 7 to 14 days after exposure and symptoms can last for a few weeks.[2] Complications are rare, though repeated episodes of serum sickness may potentially result in kidney failure.[2]
It most commonly occurs as a result of certain vaccines (such as rabies), antivenom, and immunomodulators (such as rituximab and thymoglobulin).[2][1] The underlying mechanism involves hypersensitivity, specifically immune complex hypersensitivity (type III).[1] Diagnosis may be supported by urine tests, blood tests, and a skin biopsy.[2][1]
Treatment often simple involves stopping whatever is causing the condition.[2] Antihistamines and NSAIDs may be used to improve symptoms.[2] For more severe symptoms steroids may be used.[2] If this is not effective plasma exchange may be an option.[1] Outcomes are generally excellent.[2]
Serum sickness is rare.[2] It; however, may occur in up to 27% of people treated with thymoglobulin post kidney transplant.[1] It was first described in detail by Clemens von Pirquet and Béla Schick in 1905.[3]
References
[edit]- ^ a b c d e f "Serum sickness". dermnetnz.org. DermNet NZ. Retrieved 14 February 2021.
- ^ a b c d e f g h i j Rixe, N; Tavarez, MM (January 2020). "Serum Sickness". PMID 30855896.
{{cite journal}}: Cite journal requires|journal=(help) - ^ Jackson R (October 2000). "Serum sickness". J Cutan Med Surg. 4 (4): 223–5. doi:10.1177/120347540000400411. PMID 11231202.